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In the second season of this upbeat comedy, sisters Holly (Amanda Bynes) and Valerie (Jennie Garth) have moved into a New York City loft and become well-acquainted with Hollys uncanny ability to unravel her straitlaced siblings well-ordered life. Nevertheless, Valeries own public relations firm, which she runs out of the loft with her quirky friend Lauren (Leslie Grossman), has hit the ground running. While Hollys feelings for cute messenger boy Vince (Nick Zano) have ruffled her relationship with boyfriend Henry (Michael McMillian), she tries to maintain a friendship with both boys. Meanwhile, Hollys new street-smart friend, Tina (Allison Munn), and longtime pal Gary (Wesley Jonathan) ride out all the ups and downs of living with the craziness that is Holly. No matter what happens in Hollys and Valeries unpredictable lives, one constant remains: the sisters affection and concern for each others happiness.