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Jolene Reedy (Charlize Theron) is a disillusioned single mother prone to bad men and reckless behavior. Her younger brother James (Nick Stahl) is a weak-willed underachiever who can't hold a job. But when Jolene abandons her 12-year-old daughter (Anna Sophia Robb) with James, uncle and niece make a fateful decision to flee to the farm of James and Jolene's abusive father (Dennis Hopper). in a past plagued by dark secrets, can family prove to be the most desperate bond of all? Woody Harrelson co-stars in this acclaimed Sundance Festival Premiere Selection about the cycles of love, loss and waking up to the first day of the rest of your life.