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Inspired by a true story. Upon returning home after the Civil War, former POW Jack Calgrove finds out his wife has died and his children—now presumed orphans—were loaded on a train bound for hostile territory deep in the American West. With the help of a fellow Union soldier, a troop of elite Native American sharpshooters, and a former slave searching desperately for her own daughter, Calgrove races to intercept the orphan train before all hope is lost.