Tara Gregson is a wife and mother with dissociative identity disorder (DID). After deciding to take a break from her medication to discover the real cause of her disorder, her alternate personalities re-emerge: wild and flirty teenager T; old-fashioned housewife Alice; and male, loud, beer-drinking Vietnam vet Buck. Tara is supported by her calm and level-headed husband Max, her somewhat troubled teenage daughter Kate and quirky, good-hearted gay son Marshall. Her sister, Charmaine, is not so supportive, often expressing her doubt about the validity of Tara's disorder. The show is set in Overland Park, Kansas.