With news of their grandmother's passing, a group of sisters come together to pick a song to honor their grandmother's legacy at her memorial service. While cleaning out her attic, they find old memories celebrating her life and contributions to their family and the community. In the process, they are reminded of many songs that trace the history of Black women, spanning from the days of Jim Crow, the Girl Groups of the 60's, female empowerment of the 90's and the challenges of today's youth. With hits including Oh... Happy Day, Precious Lord, Stormy Weather, R.E.S.P.E.C.T., Say a Little Prayer, Tyrone, I Have Nothing, Single Ladies, and a Woman's Worth, SISTA'S tells the evolutionary story of African-American women through popular music.