Boss Suchart is the influential owner of a major elephant camp. When he was murdered in his own home, the killer delivered three fatal blows on his body, all evidence points to KHAM (Tony Jaa), who was present at the crime scene and was seen with the victim the moment before he died. Kham is forced to run as the police launch a pursuit. Meanwhile, the twin nieces of Boss Suchart (Jija Yanin Wismitanan and Teerada Kittisiriprasert) are out for revenge. But luck is on Kham's side when he runs into Sergeant Mark (Mum Jokmok), an Interpol agent sent to Thailand on a secret mission. As Kham is hunted by several parties, he's also desperately searching for Khon, his elephant, whose disappearance is involved with Boss Suchart's death. In another twist, Kham is drawn into an underground fighting ring run by LC (RZA), a crime lord who's obsessed with collecting top-class martial artists from around the world. LC's fighters are branded only by numbers, such as the lethal, beautiful Twenty (Ratha Pho-ngam) and the diabolical NO.2 (Marrese Crump). These fighters are ordered to defeat and capture Kham for a special mission that LC has in mind.