Lisa Williams (Hilary Kennedy) and Debra Reynolds (Gwendolynn Murphy) were both enjoying evenings out when something went very wrong. Neither girl can recall what has happened as they awake locked in a dark observation room. Debra's husband, Tony, (D.C. Lee) and Lisa's boyfriend David (Manuel Velazquez) are both handcuffed to operating tables and there is no explanation. No one will respond to their calls for help and there is no way out of the room. The abducted couples are unwilling victims of a scientific experiment. As the guys recover from the anesthesia, the girls attempt to comfort them. But something strange is happening to them. The men are fighting to maintain their minds. The reasons for their abductions are unknown and they must solve the mystery soon, because their confinement isn't the biggest problem.